Fig. 7: SATB2 genomic binding is affected minimally by Mta2 loss. | Nature Communications

Fig. 7: SATB2 genomic binding is affected minimally by Mta2 loss.

From: A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin

Fig. 7

a DNA binding profiles of SATB2 that were unchanged (C1, 23,177 sites), reduced (C2, 1951 sites), or gained (C3, 700 sites) in MTA2cKO colon. Plots are 6-kb windows centered on each HNF4A binding site. b Predictions of enhancer regulatory functions by BETA (Binding and Expression Target Analysis) indicate that loss or gain of SATB2 binding in Mta2cKO colon was not associated with transcriptional changes of colonic or ileal genes. Plots depict the cumulative score of regulatory potential for every gene based on enhancer distances from the TSS. Black lines represent the background of unaltered genes, and p values denote the significance of positive or negative associations relative to the background. The P value calculated using BETA (Binding and Expression Target Analysis) which used one tail KS-test. c Genome Browser tracks showed that MTA2 regulated HNF4A genomic binding and transcriptional activation of two small intestine genes (Fabp6 and Mttp) without affecting SATB2 binding.

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