Fig. 8: Proposed two-step mechanism of lugdunin activity.
From: The antimicrobial fibupeptide lugdunin forms water-filled channel structures in lipid membranes
To exert its mechanism of action, lugdunin first inserts into lipid membranes and then self-assembles into peptide nanotubes via intermolecular hydrogen bonds. Both processes are vital for lugdunin’s antibacterial activity and are affected by different membrane and peptide properties.
