Fig. 3: Manhattan plots, marginal and main effect size comparisons. | Nature Communications

Fig. 3: Manhattan plots, marginal and main effect size comparisons.

From: An approach to identify gene-environment interactions and reveal new biological insight in complex traits

Fig. 3: Manhattan plots, marginal and main effect size comparisons.

The circle Manhattan plots of gene × alcohol drinking interactions for A LDL-C; B HDL-C; and C TG, respectively. The genome-wide significant loci are presented in red dots. The marginal and main effect sizes corresponding to alcohol drinking for D LDL-C; E HDL-C, and F TG, respectively. The colored circles represent the genome-wide significant loci and gray circles represent insignificant loci by \({T}_{{MR\_GXE}}\) test. The circle Manhattan plots of gene × cigarette smoking interactions for G LDL-C; H HDL-C; and I TG, respectively. The marginal and main effect sizes corresponding to cigarette smoking for J LDL-C; K HDL-C, and L TG, respectively.

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