Fig. 5: Cross-population comparison of the LDL-C, HDL-C, and TG marginal effect sizes of the variants reported in Graham et al.3. | Nature Communications

Fig. 5: Cross-population comparison of the LDL-C, HDL-C, and TG marginal effect sizes of the variants reported in Graham et al.3.

From: An approach to identify gene-environment interactions and reveal new biological insight in complex traits

Fig. 5: Cross-population comparison of the LDL-C, HDL-C, and TG marginal effect sizes of the variants reported in Graham et al.3.

A EUR vs AFR, no \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. B EUR vs AFR, \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. C EUR vs HIS, no \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. D EUR vs HIS, \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. E EUR vs EAS, no \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. F EUR vs EAS, \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. G AFR vs HIS, no \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. H AFR vs HIS, \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. I AFR vs EAS, no \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. J AFR vs EAS, \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. K HIS vs EAS, no \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. L HIS vs EAS, \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation. The variants with no \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation are those not included in Supplementary Data S3a. The variants with \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interaction or mediation are those in Supplementary Data S3a. We only included independent variants. The shadow error bands represent the 95% confidence intervals. Clearly the variants without \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interactions or mediations have substantially larger cross-population correlations than the variants with \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interactions or mediations, suggesting that \({{{{{\boldsymbol{G}}}}}}{{{{\times }}}}{{{{{\boldsymbol{E}}}}}}\) interactions or mediations contribute the marginal effect size heterogeneity across populations. (European (EUR), African (AFR), Hispanics (HIS), Eastern Asian (EAS)).

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