Fig. 4: Cholesterol related APOC3 showed potential as biomarker in DBT.
From: Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy
A The dot plot shows the difference of the gene set ssGSEA scores between DNP and DP samples. The dot size indicates the FDR of the adjusted two-sided permutation-based t test p values. The top related biological processes including lipid-related and neuron-related were annotated as red and orange. B Bar plot depicting the significance of lipid-related biological processes in DNP samples. C The violin plots describe the level of apolipoproteins including APOC3, APOC2, and APOL1 between DNP and DP samples. P values were derived by two-sided permutation-based t test. The line represents median, upper and lower quantiles, respectively. D The panel shows the time series-linear regression of APOC3 in 6 patients (P1, P16, P18 with all DNP samples, and P2, P3, P22 with DP samples). Dot color represents the evaluated response state. The translucent bands around the regression line indicates the 95% confidence interval. P values were derived by the two-sided F test. E The two tumor metastases radiology imaging of P16 with longitudinal samples. Source data are provided as a Source Data file.
