Fig. 1: Whole genome genetic correlations of inflammatory biomarkers with lung function parameters (FEV1, FVC, FEV1/FVC ratio, and PEF), asthma, and COPD using linkage disequilibrium score regression (LDSC).
From: Genetic association of inflammatory marker GlycA with lung function and respiratory diseases
Colors represent the magnitude of genetic correlation of each inflammatory biomarkers with lung function parameters (FEV1, FVC, FEV1/FVC ratio, and PEF), asthma, and COPD using LDSC, red for positive genetic correlation and blue for negative genetic correlation. Numbers represent the genetic correlation at nominal significance level (P < 0.05); ** represent significant genetic correlation after controlling for multiple testing (P < 0.05/30). Abbreviations: GlycA glycoprotein acetyls, hsCRP high sensitivity C-reactive protein, WBC white blood cell, FEV1 forced expired volume in 1 s, FVC forced vital capacity, PEF peak expiratory flow, COPD chronic obstructive pulmonary diseases. All P values are two-side.
