Table 5 Unadjusted and adjusted minimum detectable effect range for each stress outcome

From: A cluster-randomized trial of water, sanitation, handwashing and nutritional interventions on stress and epigenetic programming

Marker

Unadjusted minimum detectable effect rangea

Adjusted minimum detectable effect rangeb

sAA (U/ml/min)

266.41–350.48

333.22–438.38

Cortisol (µg/dl)

0.20–0.27

0.26–0.34

iPF(2α)-III

(ng/mg creatinine)

0.05–0.07

0.06–0.08

2,3-dinor-iPF(2α)-III

(ng/mg creatinine)

1.99–2.61

2.48–3.27

iPF(2α)-VI

(ng/mg creatinine)

0.51–0.67

0.64–0.84

8,12-iso-iPF(2α)-VI

(ng/mg creatinine)

1.17–1.54

1.46–1.93

NR3C1 methylation status (%)

0.92–1.21

1.15–1.51

Heart rate (beats per minute)

5.27–6.93

6.59–8.67

Mean arterial pressure (mmHg)

3.05–4.02

3.82–5.03

  1. aUnadjusted calculations using a two-sided alpha of 5%.
  2. bAdjusted for multiple comparisons using a two-sided alpha of 0.56% (0.05 / 9 outcomes).
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