Table 1 Demographics of breastfeeding women and infants

From: Population pharmacokinetic modelling of primaquine exposures in lactating women and breastfed infants

Demographics

Breastfeeding women (n = 21)

Infants (n = 21)

Age (years)

23 (18–40)

0.42 (0.13–1.81)

Sex (male/female)

0/21

14/7

Body weight (kg)

51 (35–81)

6.8 (4.13–10.8)

Haemoglobin level (mg/dL)

12.3 (10.2–14.4)

11.5 (10.5–14.2)

Haematocrit (%)

37.7 (30.5–44.2)

34.7 (33.0–43.2)

Total bilirubin level (mg/dL)

0.365 (0.19–0.74)

-

Aspartate aminotransferase (U/L)

25.5 (14–59)

-

Alanine aminotransferase (U/L)

25.5 (7–54)

-

Alkaline phosphatase (U/L)

95 (69–132)

-

Smoking status (yes)

5 (23.8%)

-

Average number of breastfeeds (/day)

11 (6–18)

-

Calculated infant daily milk intake (mL)

1020 (619–1620)

-

Number of primaquine samples ( > LLOQ / < LLOQ)

    Plasma

542 / 7

-

    Capillary

141 / 0

1 / 201

    Breast milk

200 / 6

-

Number of carboxyprimaquine samples ( > LLOQ / < LLOQ)

    Plasma

543 / 6

-

    Capillary

143 / 0

73 / 129

    Breast milk

133 / 73

-

  1. Values reported as median (min-max) unless otherwise stated. LLOQ lower limit of quantification.