Table 2 Number of amino acid mutations in different gene regions
Gene | Â | Groupa | Day 22 | Day 29 | Day 36 | Day 62 | Day 75 | Day 78 | Day 83 | Day 86 | cf BA.5.2.1 (Outbreak.info) |
|---|---|---|---|---|---|---|---|---|---|---|---|
ORF1a | Â | Major | 9 | 9 | 9 | 10 | 10 | 10 | 10 | 11 | 8 |
| Â | Â | Minor | 9 | 4 | 21 | 11 | 10 | 9 | 14 | 7 | 0 |
ORF1b | nsp12 is encoded | Major | 4 | 5 | 5 | 7 | 9 | 9 | 7 | 9 | 4 |
| Â | Â | Minor | 5 | 3 | 29 | 11 | 3 | 3 | 8 | 3 | 0 |
ORF2 | Spike protein | Major | 31 | 31 | 31 | 35 | 38 | 38 | 37 | 39 | 31 |
| Â | Â | Minor | 0 | 1 | 7 | 13 | 3 | 7 | 10 | 6 | 0 |
ORF3a | Â | Major | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Â | Â | Minor | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 |
ORF4 | Envelope protein | Major | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Â | Â | Minor | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ORF5 | Membrane protein | Major | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| Â | Â | Minor | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
ORF6 | Â | Major | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Â | Â | Minor | 2 | 3 | 2 | 0 | 0 | 2 | 1 | 0 | 0 |
ORF7a/b | Â | Major | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Â | Â | Minor | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
ORF8 | Â | Major | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
| Â | Â | Minor | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
ORF9 | Nucleocapsid protein | Major | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 6 | 4 |
| Â | Â | Minor | 1 | 1 | 1 | 3 | 2 | 3 | 2 | 2 | 0 |
ORF10 | Â | Major | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Â | Â | Minor | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
All | Â | Major | 54 | 55 | 55 | 62 | 68 | 68 | 65 | 70 | 52 |
| Â | Â | Minor | 19 | 14 | 64 | 38 | 18 | 24 | 37 | 18 | 0 |
| Â | Â | Total | 73 | 69 | 119 | 100 | 86 | 92 | 102 | 88 | 52 |
