Fig. 3: Further investigation on intramolecular systems.

A The reactions of N-deacetyl N-tosyl Colchicine sub-10 with 1b and 1c. B Selective N-arylation with other aryne precursors. C Further conversion of the TBS group on the [4 + 2]-cycloadducts.

A The reactions of N-deacetyl N-tosyl Colchicine sub-10 with 1b and 1c. B Selective N-arylation with other aryne precursors. C Further conversion of the TBS group on the [4 + 2]-cycloadducts.