Fig. 5: Early-life immune cell compositions predictive of antibody responses post-vaccination.
From: Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants
A, C Summary of ROC analysis using the latent variable axis-1 derived from partial least square discriminate analysis (PLS-DA) of NK, CD4 and CD8 T cell clusters determined to be best predictors at birth and week 4 of pertussis antibody responses at weeks 15 and rotavirus antibody response at week 36. B, D Loading variables from PLS-DA showing pre-vaccine cell clusters associated with good or poor antibody responses against pertussis and rotavirus vaccine at week 15 and 36 respectively. Sample size for each group is shown in Fig. S1.
