Fig. 10: Here we show a cell state called VC-Resist that, even if already present in naïve tumors at different levels, is strongly induced by chemoradiation and angiocrine factors from the brain blood vessels.
From: VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance
The VC-Resist cells are intermediate in the PMT and are highly resistant to therapy, vessel co-opting, senescent-like and slow-cycling. Considering our discoveries, we propose a model wherein chemoradiation leads to vessel co-option and resistance to therapy via reprogramming of GBM cells into the VC-Resist cell state. This creates a self-perpetuating cycle, as increased resistance and vessel co-option contribute to the recurrence of GBM.
