Fig. 1: Variant analysis of the hmg1 allele across clinical isolates identifies mutations associated with triazole resistance.
From: A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1
Mutations residing within the predicted sterol sensing domain (SSD) are highlighted in the green box. Triazole susceptibility phenotype, cyp51A genotype, phylogenetic relationships, and clade grouping of the clinical isolate set are indicated.
