Fig. 3: Substrate scope of decarboxylative C–N bond coupling of achiral carboxylic acids. | Nature Communications

Fig. 3: Substrate scope of decarboxylative C–N bond coupling of achiral carboxylic acids.

From: Decarboxylative stereoretentive C–N coupling by harnessing aminating reagent

Fig. 3

Reaction conditions: carboxylic acid (0.2 mmol), 3-methyl-1,4,2-dioxazol-5-one (2e, 2 equiv.) and DBU (2 equiv.) at room temperature for 4 h. Isolated yields are reported. aRun in DMF (0.2 M). bRun for 12 h. cRun with 3 equiv. of 2e at 60 oC. SCXRD stands for single crystal X-ray diffraction.

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