Fig. 4: Substrate scope of decarboxylative C(sp3)–N bond coupling of chiral carboxylic acids.
From: Decarboxylative stereoretentive C–N coupling by harnessing aminating reagent
Reaction conditions: chiral carboxylic acid (0.2 mmol), dioxazolone (2 equiv.) and DBU (2 equiv.) in DMSO (0.2 M) at room temperature for 4 h. Isolated yields are reported. aRun in DMF (0.2 M) at 0 oC for 12 h. Enantiomeric ratio (e.r.) was determined by high-performance liquid chromatography (HPLC). Diastereomeric ratio (d.r.) was determined by 1H-NMR of the crude reaction mixture.
