Fig. 2: Comparison of the bnAb sensitivity for HIV-1 Env with short (≤ 5 percentile) or long (≥ 95 percentile) hypervariable (HV) loops. | Nature Communications

Fig. 2: Comparison of the bnAb sensitivity for HIV-1 Env with short (≤ 5 percentile) or long (≥ 95 percentile) hypervariable (HV) loops.

From: Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding

Fig. 2: Comparison of the bnAb sensitivity for HIV-1 Env with short (≤ 5 percentile) or long (≥ 95 percentile) hypervariable (HV) loops.

For each panel, comparisons of IC50 values for short and long HV loops are shown for representative antibodies: PGT145 (A) and VRC26.25 (B), two V2 apex-targeting antibodies whose epitopes are close to V2HV loops; 10-1074 (C) and the PGT135 (D), two glycan supersite antibodies whose epitopes are close to V1HV loops; VRC01 (E) and 3BNC117 (F), two CD4 binding site antibodies with epitopes close to the V5HV loops. The HV loop nearest to the epitope of each antibody is shown in bold font. The box plots depicted the median and 25th/75th percentiles of the distribution, with the minima and maxima as whiskers. The p-values from non-paired, non-parametric one-tailed Mann-Whitney U tests are provided. IC50 values equal to or greater than 100 μg/ml are grouped (upper limit of antibody neutralization measurements in the CATNAP database). Source data for all panels are provided in the Source Data files.

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