Table 1 Comparison of redesigned HV loops to those found in vaccine candidates

From: Contemporary HIV-1 consensus Env with AI-assisted redesigned hypervariable loops promote antibody binding

   

V1HV

V2HV

V4HV

V5HV

Sequence

Subtype/CRF

Efficacy trials

NAAa

NPNGS

NAAa

NPNGS

NAAa

NPNGS

NAAa

NPNGS

A244

CRF01_AE

VAX003, RV144

28 (90%)

5

8 (62%)

1

9 (65%)

1

9 (75%)

2

MN

B

VAX003, VAX004, RV144

27 (81%)

3

6 (45%)

1

12 (52%)

2

10 (78%)

1

GNE8

B

VAX004

20 (36%)

2

6 (45%)

1

15 (83%)

3

7 (12%)

1

92TH023

CRF01_AE

RV144

23 (52%)

3

8 (62%)

1

9 (65%)

2

7 (27%)

2

92RW020

A1

HVTN505

9 (2%)

2

8 (61%)

1

12 (67%)

3

7 (16%)

1

HXB2

B

HVTN505

21 (43%)

2

6 (45%)

1

15 (83%)

2

8 (36%)

1

97ZA012

C

HVTN505

15 (23%)

2

11 (76%)

2

2 (9%)

0

8 (44%)

0

96ZM651

C

HVTN702

26 (86%)

4

14 (93%)

2

6 (27%)

1

12 (92%)

2

TV1

C

HVTN702

33 (98%)

4

6 (25%)

0

13 (87%)

2

9 (60%)

2

1086

C

HVTN702

12 (12%)

1

9 (62%)

1

12 (79%)

3

10 (76%)

2

Mosaic1.Env

–

HVTN705, HVTN706

25 (74%)

3

8 (61%)

2

16 (93%)

3

8 (43%)

1

Mosaic2.Env

–

HVTN705, HVTN706

21 (45%)

3

16 (97%)

2

9 (33%)

2

11 (89%)

1

CH505

C

–

12 (12%)

2

6 (25%)

1

15 (94%)

3

6 (6%)

1

WITO

B

–

19 (26%)

3

8 (68%)

1

11 (37%)

2

8 (36%)

2

DU422

C

–

21 (62%)

3

10 (70%)

1

9 (49%)

2

7 (18%)

1

BG505

A1

–

13 (8%)

2

14 (94%)

2

14 (83%)

3

8 (43%)

1

JR-FL

B

-

19 (26%)

3

6 (45%)

1

11 (37%)

2

8 (36%)

1

B_2010sb

B

-

12 (4%)

1

4 (11%)

1

11 (37%)

3

7 (12%)

2

C_2010sb

C

-

13 (16%)

1

5 (8%)

1

11 (69%)

3

7 (18%)

1

01_AE_2010s.1b

CRF01_AE

-

9 (1%)

1

5 (12%)

1

11 (84%)

3

7 (27%)

2

01_AE_2010s.2b

CRF01_AE

-

19 (8%)

1

5 (12%)

1

11 (84%)

3

7 (27%)

2

  1. aHV loop length with the percentile for this loop length in corresponding subtypes shown in parenthesis, except for Mosaic1.Env, Mosaic2.Env, and subtype A1 sequences for which a pooled set of subtype B, C, and CRF01_AE sequences was used to calculate the percentile for the specific loop length.
  2. bConsensus sequences with redesigned HV loops. 01_AE_2010s.2 includes the ‘IGNITD’ segment in the V1HV and is 10 AA longer in V1HV than 01_AE_2010s.1.
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