Fig. 2: Retrotranscriptome-wide association studies of major psychiatric disorders. | Nature Communications

Fig. 2: Retrotranscriptome-wide association studies of major psychiatric disorders.

From: Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions

Fig. 2: Retrotranscriptome-wide association studies of major psychiatric disorders.

The Manhattan biplots show the expression signatures significantly associated with (A) schizophrenia, (B) bipolar disorder, and (C) major depressive disorder. We found no HERV expression signatures associated with attention deficit hyperactivity disorder and autism spectrum conditions, so these are omitted. The X-axis indicates genomic location, whereas the Y-axis shows Z score from the TWAS. The horizontal grey lines indicate transcriptome-wide significance, i.e., a threshold adjusted for the number of expressed features using the Bonferroni method (two-sided P value cut-off = 6.10 × 10−6). Only Bonferroni-significant HERV features are labelled.

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