Fig. 4: Fine-mapping analysis supports high confidence risk HERVs for multiple psychiatric disorders. | Nature Communications

Fig. 4: Fine-mapping analysis supports high confidence risk HERVs for multiple psychiatric disorders.

From: Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions

Fig. 4: Fine-mapping analysis supports high confidence risk HERVs for multiple psychiatric disorders.

The graphs correspond to the HERV expression signals in the fine-mapping analysis that are also significant in the conditional analyses, in relation to (A) schizophrenia, including i. MER4_20q13.13, ii. ERV316A3_5q14.3j, and iii. ERV316A3_2q33.1 g; (B) bipolar disorder, which includes MER4_20q13.13; and (C) major depressive disorder, which includes ERVLE_1p31.1c. Upper part of each image: graph where the Y-axis indicates the TWAS association p value (two-sided), unadjusted for multiple testing, and the X-axis shows genetic features in the linkage disequilibrium block. The size and colour of the points indicate the posterior inclusion probability (PIP), indicating the probability that the expression feature is causal for the association signal at the locus. Lower part: correlation of predicted expression.

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