Fig. 5: Model of Rev dimer binding onto the open conformation of RRE SLII. | Nature Communications

Fig. 5: Model of Rev dimer binding onto the open conformation of RRE SLII.

From: Structure of HIV-1 RRE stem-loop II identifies two conformational states of the high-affinity Rev binding site

Fig. 5

A Rev dimer binding site in RRE SLII. The first Rev binds in the high-affinity binding site, and the second Rev likely binds in the major groove next to the high-affinity site. The two Rev-binding sites are indicated with red boxes. B First Rev binding on the initial high-affinity binding site. Rev arginine-rich motif (ARM) and two oligomerization domains (OD) are shown in beige and brown, respectively. The ARM of the first Rev molecule was placed within the widened major groove formed by 8GGG10 of the open SLII conformer. C Second Rev molecule binding within stem IIC. The ARM of the second Rev molecule was placed within the major groove at the base of stem IIC. D Binding of the Rev dimer on the open SLII conformation. The Rev dimer is stabilized by the interaction of the ARM domains within the RNA major grooves as well as between neighboring Rev ODs.

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