Fig. 2: Comparison of the reported geometric mean vaccinia-binding titers induced by vaccination with MVA-BN (n = 12) and historic first-generation vaccines (n = 3).

The GMTs from the freeze-dried MVA-BN formulation (n = 5, light-color) are higher than the liquid frozen formulation (n = 8, dark-color). That is, the ratio of titers in the freeze-dried and liquid frozen formulations (median of the posterior distribution) is 1.32-fold (95% credible interval:1.20−1.48). The points and error bars indicate the GMT reported in each study, along with 95% confidence bands extracted from each study respectively. Horizontal lines indicate the combined estimate (median of the posterior distribution) for each vaccination and formulation (shaded regions are the 95% credible intervals). The different colours represent the different vaccines with one and two doses of MVA-BN coloured differently.