Fig. 6: Incident, atrial fibrillation risk, stratified by left atrial polygenic score.
From: Deep learning of left atrial structure and function provides link to atrial fibrillation risk
Disease incidence curves for the 417,881 participants who were unrelated to within three degrees of the participants who underwent MRI in the UK Biobank. Those in the top 5% for the BSA-indexed LAmin PRS are depicted in red; the remaining 95% are in gray. The lighter-shaded bands around each line represent the 95% confidence interval. X axis: years since enrollment in the UK Biobank. Y axis: cumulative incidence of AF (19,875 cases in the bottom 95% and 1272 cases in the top 5%). Those in the top 5% of genetically predicted LAmin indexed had an increased risk of AF (Cox HR 1.19, P = 7.9E-10) compared with those in the remaining 95% in up to 12 years of follow-up time after UK Biobank enrollment.
