Table 2 GWAS lead SNPs

From: Deep learning of left atrial structure and function provides link to atrial fibrillation risk

Trait

CHR

BP

dbSNP

Effect Allele

Other Allele

EAF

BETA

SE

P

Nearest gene

LAmax

6

31294375

rs9265346

G

A

0.33

0.045

0.007

1.10E-09

HLA-B

LAmax

6

79554193

rs6926537

T

A

0.512

−0.039

0.007

9.10E-09

IRAK1BP1

LAmax

6

107433645

rs60237682

T

C

0.683

−0.041

0.007

3.80E-08

BEND3

LAmax

12

66343400

rs1038196

G

C

0.486

0.039

0.007

1.10E-08

HMGA2

LAmax

19

46213416

rs62111731

A

G

0.479

0.042

0.007

7.10E-10

FBXO46

LAmax indexed

2

179650954

rs6715901

G

A

0.507

−0.043

0.008

1.20E-08

TTN

LAmax indexed

4

111665783

rs2634073

T

C

0.166

0.057

0.01

2.00E-08

PITX2

LAmax indexed

5

32831670

rs13154066

T

C

0.402

−0.05

0.008

6.60E-11

NPR3

LAmax indexed

6

31229203

rs9264391

G

A

0.893

−0.089

0.014

9.30E-11

HLA-C

LAmax indexed

6

107442277

rs9480737

A

G

0.682

−0.05

0.008

8.80E-10

BEND3

LAmax indexed

19

46166806

rs140153691

T

TGC

0.639

−0.047

0.008

4.10E-09

GIPR

LAmax indexed

22

26156505

rs133873

T

A

0.775

−0.055

0.009

9.60E-10

MYO18B

LAEF

1

51322205

rs79948214

A

G

0.984

0.161

0.029

4.70E-08

FAF1

LAEF

1

116310967

rs4074536

T

C

0.702

−0.052

0.008

7.80E-11

CASQ2

LAEF

14

23874117

rs440466

T

C

0.622

0.056

0.008

7.30E-14

MYH6

LAEF

22

26159289

rs133885

G

A

0.548

0.046

0.007

3.60E-10

MYO18B

LAmin

6

31294375

rs9265346

G

A

0.33

0.044

0.007

8.30E-09

HLA-B

LAmin

6

79518638

rs35790661

C

CCA

0.63

−0.043

0.007

4.40E-09

IRAK1BP1

LAmin

6

107442277

rs9480737

A

G

0.682

−0.041

0.007

3.10E-08

BEND3

LAmin

10

92681480

rs780162510

CATA

C

0.49

0.04

0.007

2.20E-08

ANKRD1

LAmin

11

65336819

rs3782089

C

T

0.928

0.074

0.013

4.70E-08

SSSCA1

LAmin

15

99248018

rs4966014

C

T

0.3

0.045

0.008

4.20E-09

IGF1R

LAmin

19

46315357

 

AT

A

0.476

0.047

0.007

1.20E-11

RSPH6A

LAmin

22

26164079

rs133902

C

T

0.56

−0.041

0.007

4.30E-09

MYO18B

LAmin indexed

2

3912741

rs56289263

C

T

0.938

−0.093

0.017

4.40E-08

DCDC2C

LAmin indexed

2

179650954

rs6715901

G

A

0.507

−0.041

0.007

4.50E-08

TTN

LAmin indexed

4

24289655

rs1533093

C

T

0.862

−0.062

0.011

3.80E-08

DHX15

LAmin indexed

4

111665783

rs2634073

T

C

0.166

0.057

0.01

1.20E-08

PITX2

LAmin indexed

5

32831670

rs13154066

T

C

0.402

−0.043

0.008

1.40E-08

NPR3

LAmin indexed

6

31294375

rs9265346

G

A

0.33

0.047

0.008

1.00E-08

HLA-B

LAmin indexed

6

107442277

rs9480737

A

G

0.682

−0.049

0.008

1.00E-09

BEND3

LAmin indexed

8

97223162

rs35216833

C

T

0.456

0.042

0.007

1.00E-08

UQCRB

LAmin indexed

10

92586289

rs112343361

A

ACT

0.497

−0.046

0.008

1.80E-09

HTR7

LAmin indexed

15

99248018

rs4966014

C

T

0.3

0.047

0.008

1.80E-08

IGF1R

LAmin indexed

17

45097337

rs8078336

G

T

0.965

−0.137

0.025

2.70E-08

GOSR2

LAmin indexed

19

46292259

rs7246377

G

A

0.534

−0.049

0.007

2.80E-11

DMWD

LAmin indexed

22

26156512

rs133874

A

G

0.773

−0.061

0.009

6.80E-12

MYO18B

LASV

6

31225196

rs199610865

T

TA

0.853

−0.055

0.01

2.90E-08

HLA-C

LASV

14

23869029

rs376439

A

G

0.606

0.045

0.007

2.70E-10

MYH6

LASV indexed

6

31225196

rs199610865

T

TA

0.853

−0.067

0.011

4.70E-10

HLA-C

LASV indexed

9

136138765

rs8176685

GCGCCCACCACTA

G

0.82

−0.059

0.01

3.20E-09

OBP2B

LASV indexed

14

23869029

rs376439

A

G

0.606

0.048

0.008

8.10E-10

MYH6

  1. BP GRCh37-base position, dbSNP dbSNP identifier, where available, EAF Effect allele frequency, BETA BOLT-LMM effect size of the effect allele, in units of the rank-based inverse normal transform which approximates a standard deviation change. SE standard error. P two-tailed BOLT-LMM P value. “Indexed” indicates that the trait has been divided by body surface area. Gene names are italicized.
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