Fig. 6: Structural comparison of NikA:Ni-AMA to known ligand-bound structures of NikA. | Nature Communications

Fig. 6: Structural comparison of NikA:Ni-AMA to known ligand-bound structures of NikA.

From: Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes

Fig. 6

A Surface representation of NikA apoprotein in its open form (PDB 4UIU) compared to the Ni-AMA bound form of NikA. AMA and Ni2+ are shown as sticks (gray) and spheres (green). B Structural superposition of NikA:Ni-AMA (light blue), NikA:Ni(l-His)2 (PDB ID 4I8C; yellow), NikA:Ni-BTC (PDB ID 3DP8; teal), NikA:Fe-EDTA (PDB 1ZLQ; orange), and NikA apoprotein (PDB 1UIU; white) aligned relative to lobe-I (gray) shown in ribbon representation. C Structural comparison of Ni2+ complexes from B. Complexes are colored according to the scheme from B, except His416, which is shown as white sticks. D Cartoon detail of the lobe-II overlay from B showing NikA:Ni-AMA (blue) and NikA:Ni-(l-His)2 (yellow). Ni-AMA (white) and Ni-(l-His)2 (yellow) are shown in stick representation.

Back to article page