Fig. 7: VP GABA and glutamate neurons evoke opposite activity pattern in VTA cell types. | Nature Communications

Fig. 7: VP GABA and glutamate neurons evoke opposite activity pattern in VTA cell types.

From: Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

Fig. 7

A AUC of ΔF/F (%) was calculated from VTA cell-type responses during 5 s passive stimulation of VP GABA and Glut neurons (5 s, 40 Hz; 20 s ISI) and show opposite response patterns. AUC of ΔF/F from VTA cell-type responses to 5 s VP GABA stimulation during the RTPP assay (including only entries preceded by at least 2 s in the inactive side, followed by at least 5 s in active side) evokes smaller responses in VTA DA and Glut neurons (n = 5 mice for VP GABA – VTA DA and VP GABA – VTA GABA, n = 6 mice for VP Glut – VTA DA and VP Glut – VTA GABA, n = 7 mice for VP Glut – VTA Glut, and n = 8 mice for VP GABA – VTA Glut). Data are represented as mean ± SEM. B Functional connectivity model by which VP GABA and glutamate neurons differentially recruit activity within VTA cell types. Source data are provided as a Source Data file.

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