Fig. 3: Structured optogenetic stimulation selectively biases cortical responses.
From: Self-organization of modular activity in immature cortical networks
a Experimental schematic. Patterned optogenetic stimulation with 3 arbitrary patterns that approximate the wavelength of endogenous activity. b Individual opto-evoked events are variable and show partial overlap with stimulus input. c Mean response across trials shows strong overlap with stimulus pattern. d Trial-to-trial event correlations show elevated similarity for responses evoked by the same stimulus pattern. e Opto-evoked events specifically reflect the input stimulus pattern. Data from same example animal in d. Across animals, both opto-evoked individual event responses (f) and trial averaged responses (g) were significantly more similar to their respective stimulus input pattern than trial shuffled controls. * indicates p values < 0.05. f Each open circle shows the mean (+/−SEM) similarity to input pattern across individual trials pooled across stimulus patterns for each animal (n = 40 trials per n = 3 stimulus patterns, total 120 trials), compared to trial-shuffled controls. Closed circle indicates across animal mean (+/−SEM), n = 7 animals, p = 0.008, one-sided WSR (g) Open triangle shows similarity of mean response pattern to input averaged (+/−SEM) across n = 3 stimuli. Closed triangle indicates across animal mean (+/−SEM), n = 7 animals, p = 0.008, one-sided WSR.
