Fig. 7: Sox17-Erg directly reprograms cardiac fibroblasts in vivo.
From: Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg
a Schematic of in vivo iEC reprogramming. b Quantification of percent PECAM1+ GFP+ Tcf21-tdTomato+ of GFP+ Tcf21-tdTomato+ cells in Day 7 hearts (n = 5 animals) (two-sided Mann–Whitney test; mean with SD). Two representatives deconvolved low magnification images of Day 7 GFP control (c) and SEG (e) samples (scale bars 100 µm). Higher magnification deconvolved images of GFP (d) and SEG (f) samples (scale bars 20 µm). g Additional image of in vivo iECs within region of interest (h) (scale bars 10 and 3 µm). Yellow arrows indicate GFP+ tdTomato+ PECAM1− cells. Blue arrows indicate GFP+ tdTomato+ PECAM1+ cells. Source data are provided as a Source Data file.
