Fig. 1: Schematic representation of benchmarking workflow.
From: Benchmarking of methods for DNA methylome deconvolution
Panel 1: selection of cell-specific markers using a reference dataset. Panel 2: construction of in silico mixtures from an independent validation dataset. Panel 3: normalization and deconvolution of bulk DNA methylation signals derived from in silico mixtures. Panel 4: deconvolution performance assessment based on root mean squared error, Spearman’s R2, Jensen–Shannon divergence, and combined summary metric.
