Fig. 3: Reaction condition optimization and the substrate scope of d2-alkyl TT salts in metallaphotoredox deuteroalkylation.
From: Metallaphotoredox deuteroalkylation utilizing thianthrenium salts
a Optimizations of the reaction of aryl bromide 4a using TT salt 2a. b The scope of d2-TT salts coupled with aryl bromide 4a. Standard reaction conditions: aryl bromide 1c (0.2 mmol), TT salt (0.4 mmol), 4CzIPN (1.0 mol%), NiBr2•dtbpy (5.0 mol%), TMS3SiH (0.22 mmol), Cs2CO3 (0.4 mmol), LiBr (0.4 mmol), MeOAc (1.6 mL)/DMSO (0.4 mL), Blue LEDs, r.t., 24 h, isolated yields, deuterium incorporation was determined by 1H NMR spectroscopy and/or HRMS.
