Table 1 Targets and mutational profiles of the three patients
From: Drug screening on digital microfluidics for cancer precision medicine
Genes | Target drugs | Patient #1 | Patient #3 | Patient #5 | |||
|---|---|---|---|---|---|---|---|
Apatinib | Lenvatinib | Regorafenib | Sorafenib | ||||
TP53 | + | – | + | ||||
ALK | + | – | – | ||||
NF1 | + | – | – | ||||
MET | – | +↑ | – | ||||
RET | √ | √ | √ | √ | – | – | – |
FGFR1 | √ | √ | √ | – | – | – | |
FGFR2 | √ | √ | – | – | – | ||
FGFR3 | √ | – | – | – | |||
FGFR4 | √ | – | – | – | |||
BRAF | √ | √ | – | – | – | ||
PDGFR-α | √ | √ | – | – | – | ||
KIT | √ | √ | √ | √ | – | – | – |
