Fig. 8: The proposed model for the interplay between divalent metal ions and 8–17 DNAzyme structure and activity.
From: The 8-17 DNAzyme can operate in a single active structure regardless of metal ion cofactor
The top part of the scheme represents the conformational ensemble of the apo- form of the enzyme, while the effects of Pb2+ and Zn2+ ions are depicted below in the left and right panels, respectively. The occupation state of structural and catalytic metal binding sites is also shown in each case for the well-folded DNAzyme molecules. When the catalytic site is filled the DNAzyme is activated, as marked by the black, highlighted scissors.
