Fig. 4: Changes in EV-associated HIV RNA is correlated with changes in neurocognitive dysfunction.
From: HIV-1 RNA in extracellular vesicles is associated with neurocognitive outcomes
a Correlation matrix using Spearman’s correlations between linear model-estimated slopes (change per year) for each individual (n = 43) on each parameter across time. The correlation matrix uses color (blue = positive; red = negative) to depict the two-sided pairwise Spearman correlation (without adjustments for multiple comparisons) results. Significant correlations were shown, while non-significant correlations were omitted (white). b Negative correlation between the change in CSF Long LTR copy number and the change Executive Functioning domain score over time (r = −0.332, p = 0.03). c Positive correlation between the change in Serum TAR copy number and the Global Deficit Score over time (r = 0.309, p = 0.044). The gray region represents pointwise 95% confidence intervals and gray line represents the unadjusted r. CSF cerebrospinal fluid, TAR transactivation response element, LTR long terminal repeat, GDS global deficit score. Source data are provided as a Source Data file.
