Fig. 3: Correlation between histological collagen density maps and DBSI collagen fraction maps.
From: Whole cervix imaging of collagen, muscle, and cellularity in term and preterm pregnancy
a Trichrome images of the specimens and 10× magnified views of the black-dashed-boxed regions. The magnified views of P1-S2 show examples of dense organized collagen fibers in the subglandular (SG) region and loose disorganized collagen fiber near the ectocervix, which are reflected on both histological density and DBSI maps. b, c Comparison of histological collagen density maps (b) and DBSI-derived collagen fraction maps (c). d Pearson correlation coefficients (two-sided, at 0.05 significance level) between DBSI collagen fiber fraction and histology collagen fiber density. Each blue dot represents the mean value from a 2.5 × 2.5 mm white grid box within the specimen’s contour in (b) and (c). Red lines indicate linear fits, and shaded areas indicate 95% confidence intervals. p = 4.51 × 10−8, 3.30 × 10−13, 1.65 × 10−9, 6.57 × 10−4 from P1-S1 to NP1-S1, respectively. Source data are provided as a Source Data file.
