Fig. 7: Schematic summary of the effect of supercoiling mediated chromatin loop extrusion on chromatin distribution in the nucleus. | Nature Communications

Fig. 7: Schematic summary of the effect of supercoiling mediated chromatin loop extrusion on chromatin distribution in the nucleus.

From: Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization

Fig. 7: Schematic summary of the effect of supercoiling mediated chromatin loop extrusion on chromatin distribution in the nucleus.

a A schematic of the roles of epigenetic and transcriptional regulation in chromatin compaction and b the steps in extrusion of a chromatin loop (Eq. 5). c Schematics showing the alterations in chromatin compaction and supercoiling mediated loop extrusion upon inhibition of the proteins involved in the individual steps of loop extrusion. Note that nucleosomes, despite being present, are not represented to better display the chromatin loops.

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