Fig. 2: Activity evolves through time across layers during a seizure.

A Example in a single participant having two laminar electrodes of change of the CSD over time for a seizure recorded within the ictal onset zone (top) and outside the ictal onset zone (bottom). The start and end of seizures are marked with red arrows. The red lines represent the CSD distribution across the cortex and the clear change in the CSD spread for seizures outside the onset zone. Insets in the middle show an expanded view of the CSD at different time points. B Average representation of CSD evolution across all participants and seizures during seizures recorded within the ictal onset zone (upper matrix) and outside of the ictal onset zone (bottom matrix). The values correspond to the normalized distribution of the absolute values of CSD (thus combining sink and source) differing significantly from the baseline.