Fig. 6: CoGAPs gene expression immunophenotypes map sepsis trajectories.

a Scatter plot comparing values of pattern 4 (associated with health) and pattern 23 (associated with septic shock). Point size indicates the collection times (0, 6, 24, 48, 72 h, 28 days, 6 and 12 months) and the point fill corresponds to healthy donors (H, gold), survivors (tan), and those who died by 28 days (red). The line and arrow with a green background correspond to the mean trajectory of the survivors (dark tan), and those who died by 28 days (dark red). The second column shows individual group data plots where the sample collection time is represented in greyscale. The last column shows the paths of all the survivors (tan), and non-survivors (red). b Selected surviving subject trajectories using pattern 23 and pattern 4. c Barplot showing the change in health-related patterns (P4, P27, P12) and sepsis-related patterns (P23, P14, P15) over time for select surviving subjects showing dynamic recovery over time. d Model highlighting the opportunities to target treatable traits of phenotypes revealed by analysis of gene expression patterns in this study that describe sepsis survival or death.