Fig. 4: Associations between physical frailty, inflammatory markers, and depression incidence in matched data. | Nature Communications

Fig. 4: Associations between physical frailty, inflammatory markers, and depression incidence in matched data.

From: The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression

Fig. 4: Associations between physical frailty, inflammatory markers, and depression incidence in matched data.The alternative text for this image may have been generated using AI.

A The propensity score matching procedure generated two groups of 11,241 frail and non-frail participants who were matched on all 10 covariates. The risk of depression for frail people was 3.08-fold higher than the matched non-frail people. The size of the bar represents mean HRs. The error bar represents the corresponding 95% CI. B Significant differences between frail and non-frail individuals were observed for all inflammatory markers other than lymphocytes (two-sided T test). Boxplot elements were defined as follows: the center line is the median value; box limits are the upper and lower quartiles; whiskers are 1.5× the interquartile range. C Of all inflammatory markers, only CRP, neutrophils, and leukocytes significantly mediated the prospective association between frailty and depression incidence (frail vs non-frail: n = 11,241 vs n = 11,241). The significance of mediating effects was determined based on 5000 bootstrap iterations. Path thickness indicates the strength of associations, and numerical values for the largest and smallest effect sizes are provided for reference. Dots: mean HRs; Horizontal lines: 95% CI. CRP C-reactive protein. HR hazard ratio. Icons were made from https://www.svgrepo.com/. Source data are provided as a Source Data file.

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