Fig. 7: The interaction of the three miRNAs with the 21 gene targets from the NASA Twin Study in Monocytes.
From: Space radiation damage rescued by inhibition of key spaceflight associated miRNAs
a Cumulative plots for change over time with the 21 genes targeted by the three miRNAs using RNA-seq data from the NASA Twin Study data. Sequencing was performed on lymphocyte depleted cells (i.e. monocytes) from the Twin that was onboard the ISS for 340 days. There are comparisons over time starting with Flight versus Pre-Flight as well as comparing the different Return (R) to Earth timepoints from 1 to 200 days versus Pre-Flight. b Correlation plot of the three miRNAs (i.e. miR-16-5p, let-7a-5p, and miR-125b-5p) and the 21 gene targets for the overlapping time points from the miRNA-seq and mRNA-seq NASA Twin Study data. The gene targets for the miRNAs are indicated in the outer black (yes for gene target) and gray (no for gene target) rows and columns. Wald test and the likelihood ratio test was used to generate the F statistic p-value and significance for the correlation is shown by *p-value < 0.05.
