Table 1 Fluoride resistance phenotypes and transport rates of fluoride export proteins
Species | Exporter Type | Genetic Knockout | Transport rate (ions/s) | Structure (PDB) |
|---|---|---|---|---|
Escherichia coli | Fluc homodimer | MIC WT: 200 mM67 MIC KO: ~1 mM67 |  |  |
Streptococcus mutans | CLCF | IC50 WT: ~150 mM132 IC50 KO: ~0.2 mM68 | 81068 |  |
Streptococcus sanguinus | Fluc heterodimer | IC50 WT: ~300 mM132 KO: no growth at 75 mM132 |  |  |
Streptococcus anginosus | CLCF | IC50 WT: ~300 mM132 IC50 KO: no growth at 75 mM132 |  |  |
Aspergillus fumigata | FEX | MIC WT: 100 mM111 MIC KO: 1.56 mM111 |  |  |
Pseudomonas putida KT2440 | Fluc homodimer | IC50 WT: ~50 mM21 IC50 KO: ~1 mM21 |  |  |
Bordetella pertussis | Fluc homodimer | Â | >105 81 | 5A4083 |
Enterococcus casseliflavus | CLCF | Â | 6D0J79 | |
Escherichia coli virulence plasmid | Fluc homodimer |  | >105 81 | 5A4383 |
Lactobacillus acidophilus | Fluc heterodimer |  | >105 81 |  |
Piruella staleyi | CLCF | Â | Â | |
Candida albicans | FEX | IC50 WT: 140 mM85 IC50 KO: .098 mM85 |  |  |
Sacchaomyces cervisiae | FEX | IC50 WT: 70 mM85 IC50 KO: .06 mM85 | >105 133 |  |
Arabidopsis thailana | FEX | WT MIC (seed germination): 4 mM133 KO MIC (seed germination): 0.1 mM133 | >105 133 |  |
