Fig. 5: Anti-CSP IgG levels and CD69 + CD8 + CCR7-CD45RO+ T cells are positively correlated with patency day. | Nature Communications

Fig. 5: Anti-CSP IgG levels and CD69 + CD8 + CCR7-CD45RO+ T cells are positively correlated with patency day.

From: Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms

Fig. 5: Anti-CSP IgG levels and CD69 + CD8 + CCR7-CD45RO+ T cells are positively correlated with patency day.

A Patency day (number of days from mosquito exposure to a positive peripheral blood smear) for each CHMI participant is plotted against their anti-CSP IgG level determined by ELISA on D1, DRx or DRx +7 (CHMI 1 n = 8, CHMI 2 n = 8, CHMI 3 n = 8, CHMI 4 n = 5). B Patency day from CHMI 2 to CHMI 4 for each participant that completed all 4 CHMIs (n = 5) is plotted against the number of CD69 + CD8 + CCR7-CD45RO+ T cells detected using flow cytometry of unstimulated PBMC isolated after the same CHMI 7 days after treatment (DRx+7). All six participants that completed the mock CHMI were included in the flow cytometry analysis, (CHMI 1 n = 6, CHMI 2 n = 6, CHMI 3 n = 5, CHMI 4 n = 4). Statistical analysis was determined by Spearman correlation (GraphPad Prism 9). Rho = correlation coefficient and the two-sided P values (p) are shown. Source data are provided as a Source Data file.

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