Fig. 7: CD8 + CCR7-CD45RO-CXCR6 + T cells decrease and CD8 + CCR7-CXCR5 + T cells increase after repetitive CHMI. | Nature Communications

Fig. 7: CD8 + CCR7-CD45RO-CXCR6 + T cells decrease and CD8 + CCR7-CXCR5 + T cells increase after repetitive CHMI.

From: Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms

Fig. 7: CD8 + CCR7-CD45RO-CXCR6 + T cells decrease and CD8 + CCR7-CXCR5 + T cells increase after repetitive CHMI.

Flow cytometry was used to analyze PBMC collected 7 days after treatment (DRx+7) from all participants that completed the mock CHMI analysis (C1 n = 6, C2 n = 6, C3 n = 5, C4 n = 4). A The number of cells per 200,000 total cells and percent of CD3 + CD8 + CCR7-CD45RO- (effector) T cells positive for CXCR6 or CXCR5. B The number of CD3 + CD8 + CCR7-CD45RO+ (effector memory) cells per 200,000 total cells positive for CXCR3 or PD-1. C The number and percent of PD-1 + CD8 + CCR7 + CD45RO+ (central memory) T cells. D The number and percent of CXCR5 and PD-1 positive CD8 + T cells, CD8 + CCR7-CD45RO−, CD8 + CCR7-CD45RO+ and CD8 + CCR7 + CD45RO + T cells. Data are presented as mean values +/− standard error of the mean (SEM). Statistical differences were determined using Dunnett’s multiple comparisons test between CHMI 1 and CHMI 2-4 and all P values are two-sided. Source data are provided as a Source Data file.

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