Fig. 5: Predictions of fibrillation-prone regions of the CT sequence. | Nature Communications

Fig. 5: Predictions of fibrillation-prone regions of the CT sequence.

From: Structural conversion of the spidroin C-terminal domain during assembly of spider silk fibers

Fig. 5

The CT sequence with the positions of the helices in the model of the soluble CT shown as comparison. Amino acid residues with β-sheet chemical shifts from ssNMR are indicated in red. Computational analysis using ZipperDB fibrillation propensity and theoretical inter-sheet distances in combination with TANGO cross-β aggregation at pH 7 and pH 4 suggest hotspots for possible formation of β-sheets.

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