Fig. 7: The proposed model for α-helix to β-sheet structural conversion of the CT domain and the helix No4 peptide. | Nature Communications

Fig. 7: The proposed model for α-helix to β-sheet structural conversion of the CT domain and the helix No4 peptide.

From: Structural conversion of the spidroin C-terminal domain during assembly of spider silk fibers

Fig. 7

The complete CT domain forms fibers, as presented with scanning electron microscopy (left side). The C-terminal segment helix No4 refolds from α-helix to β-sheet to form a supramolecular β-sheet structure at a hydrophobic/hydrophilic interface. Helix No4 (peptide CT51–80) has been shown to form fibrils under acidic pH, as shown by AFM (right side). Glu is shown in red, Arg in blue, Cys in orange, and helix No4 in yellow.

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