Fig. 1: Design of bivalent degraders targeting the DENV E protein. | Nature Communications

Fig. 1: Design of bivalent degraders targeting the DENV E protein.

From: Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism

Fig. 1

A Structure of the soluble DENV2 prefusion E protein with βOG bound in the pocket located between domains I and II (PDB:1OKE). Note that only one monomer of the prefusion E is illustrated here for visual simplicity. B Structure of the DENV2 immature prM-E proteins (PDB:3C6E). Only one monomer of the immature trimer is shown. Domains I (red), II (yellow), III (blue), βOG (green), and prM (pink) are shown. C Chemical structures of GNF-2 and 2-12-2. D DENV E PROTACs GNF-2-deg, 2-12-2-deg, and their corresponding negative control compounds, GNF-2-deg-BUMP and 2-12-2-deg-BUMP, in which truncation of the carbonyl group at the glutarimide disrupts the CRBN-binding moiety.

Back to article page