Fig. 3: Diversifications of desired peptide aldehyde.
From: Electrochemical synthesis of peptide aldehydes via C‒N bond cleavage of cyclic amines
Isolated yields are reported. [a] NaBH4, MeOH, 0 °C, 1 h. [b] (i) NaBH4, MeOH, 0 °C, 1 h; (ii) DAST, DCM, −78 °C to RT, 14 h. [c] (i) NaBH4, MeOH, 0 °C, 1 h; (ii) MsCl, Et3N, DCM, 0 °C to RT, 4 h; (iii) NaN3, DMF, RT, 12 h. [d] PPh3MeBr, t-BuONa, THF, 0 °C to RT, 12 h. [e] O2, NHPI, MeCN, RT, 12 h. [f] Transformations of hydroxyl peptides. [g] Applications of acid products. For details, please see the Supplementary Information on pages 57−69.
