Fig. 1: The switch from FOXA1 to FOXA2 promotes lineage reprogramming of CRPC.
From: FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer
a PDX-201.1A-Cx (201.1) and PDX-201.2A-Cx (201.2) were derived from distinct metastases from a single patient (201.1—dura; 201.2—lung). b Relative expression of FOXA1 and FOXA2 in these PDXs and LNCaP cells based on bulk RNA-seq data (201.1 n = 4 independent tumor samples; 201.2 n = 3 independent tumors; data represented as mean ± SEM; statistical significance determined by unpaired two-sided t-test). c GSEA for transcriptomes (RNA-seq) of PDX201.2 versus PDX201.1. d Heatmap view for the ChIP-FOXA1 or FOXA2 centered at the FOXA1 and FOXA2 binding sites in these two PDX models. The intensity of the colors represents the signal strength, with red indicating a higher signal and blue indicating a lower signal. e, f BETA integrating ChIP-FOXA1 peaks in 201.1 (e) or ChIP-FOXA2 peaks in 201.2 (f) with RNA-seq data of PDX201.2 versus PDX201.1. g Gene ontology (GO) annotation for potential direct targets of FOXA1 in PDX201.1 and FOXA2 in PDX201.2 (identified from BETA). ns (P > 0.05), *(0.01 < P < 0.05), **(0.001 < P < 0.01), ***(P < 0.001), and ****(P < 0.0001) were used to indicate the levels of P-value. Source data are provided as a Source Data file. a Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en.
