Fig. 9: FOXA2 transcription programs are activated in a subset of AR-dependent CRPC tumors.
From: FOXA2 rewires AP-1 for transcriptional reprogramming and lineage plasticity in prostate cancer
a Heatmap view for GSVA scores of model-specific FOXA2 targets in different PCa cell lines. b GSEA for the enrichment status of indicated FOXA2-target gene sets in LN-FOXA2-OE versus control cells or in LN-FOXA2-OE cells transfected with/out siJUN. Left column: the red color indicates enriched pathways for upregulated genes by FOXA2-OE; Right column: the blue color indicates enriched pathways for genes downregulated by JUN silencing. c qRT-PCR for the mRNA expression of indicated FOXA2 targets in the control LNCaP cells and LN-FOXA2-OE cells transfected with/out siJUN (n = 3 independent samples; data represented as mean ± SEM; statistical significance determined by unpaired two-sided t-test). d Heatmap view for GSVA scores of model-specific FOXA2 targets or FOXA2/JUN co-targets in SU2C mCRPC samples (n = 206 samples). e Graphic model for the functional switch from FOXA1 to FOXA2 in reprogramming JUN and driving lineage plasticity. ns (P > 0.05), *(0.01 < P < 0.05), **(0.001 < P < 0.01), ***(P < 0.001), and ****(P < 0.0001) were used to indicate the levels of P-value. Source data are provided as a Source Data file. e Created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en.
