Table 2 Top ten genes significantly differentiated between cell types in expression variance while not in mean (\({{{{{\boldsymbol{p}}}}}} > {{{{{\boldsymbol{0.01}}}}}}\)) in REML, meanwhile significantly differentiated in variance in HE, with CTP data
From: A robust model for cell type-specific interindividual variation in single-cell RNA sequencing data
Gene | REML | HE | Function | ||
|---|---|---|---|---|---|
\(p({{{{{{\mathrm{variance}}}}}}})\)a | \(p({{{{{{\mathrm{mean}}}}}}})\)b | \(p({{{{{{\mathrm{variance}}}}}}})\) | \(p({{{{{{\mathrm{mean}}}}}}})\) | ||
NDUFB4 | \(1.93\times {10}^{-19}\) | \(0.014\) | \(9.62\times {10}^{-15}\) | \(0.125\) | Cell differentiation50 |
NUTF2 | \(1.06\times {10}^{-17}\) | \(0.109\) | \(1.16\times {10}^{-16}\) | \(0.081\) | |
SLX1A | \(6.11\times {10}^{-15}\) | \(0.162\) | \(7.17\times {10}^{-18}\) | \(0.202\) | Genome stability57 |
EIF4A1 | \(2.29\times {10}^{-13}\) | \(0.011\) | \(2.11\times {10}^{-10}\) | \(0.698\) | Stem cell self-renewal58 |
TFPI2 | \(4.84\times {10}^{-13}\) | \(0.024\) | \(7.30\times {10}^{-9}\) | \(0.057\) | Cell proliferation59 |
ATP5J2 | \(6.30\times {10}^{-13}\) | \(0.093\) | \(1.09\times {10}^{-13}\) | \(0.012\) | ATP synthesis60 |
SMAP1 | \(1.02\times {10}^{-12}\) | \(0.024\) | \(5.96\times {10}^{-10}\) | \(0.049\) | Cell growth61 |
NDN | \(1.80\times {10}^{-12}\) | \(0.011\) | \(8.21\times {10}^{-10}\) | \(0.079\) | Cell growth62 |
KRT10 | \(2.40\times {10}^{-12}\) | \(0.218\) | \(1.16\times {10}^{-10}\) | \(0.403\) | Â |
NDUFA1 | \(4.28\times {10}^{-12}\) | \(0.406\) | \(2.64\times {10}^{-11}\) | \(0.702\) | Cell differentiation50 |
