Fig. 4: ROS generation properties and bactericidal activities of TQ/PS1 complex. | Nature Communications

Fig. 4: ROS generation properties and bactericidal activities of TQ/PS1 complex.

From: Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers

Fig. 4: ROS generation properties and bactericidal activities of TQ/PS1 complex.The alt text for this image may have been generated using AI.

a GC-MS analysis of photoinduced oxidization of CA in the presence of PS1 with or without light irradiation. b Comparison of the PL intensity of DHR 123 with the addition of different concentrations of TQ (0-100 µg/mL) in the presence of PS1 (4 µg/mL) under light irradiation. c Comparison of the PL intensity of DHR 123 with or without radical scavenger under light irradiation. CFU counts of S. aureus treated with TQ/PS1 (PS1 4 µg/mL, TQ 8 µg/mL), PS1 (4 µg/mL), or TQ (8 µg/mL) under normoxic (d) or hypoxic (e) conditions in the presence or absence of light irradiation (60 mW/cm2, 10 min). f Abolishment of the antibacterial activities by the addition of O2−• scavenger VC in the presence of TQ/PS1 complex (PS1 4 µg/mL, TQ 8 µg/mL). Data in (b–f) are presented as mean ± SD derived from n = 3 independent samples. Statistical significance was analyzed via one-way (b, c, f) or two-way (d, e) ANOVA test with a Tukey post hoc test. ns no significance.

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