Fig. 1: Carboxylate directed meta-C–H alkylation as an unmet catalytic challenge.
From: Ligand-enabled ruthenium-catalyzed meta-C−H alkylation of (hetero)aromatic carboxylic acids
a Carboxylate groups directed C(sp2)-H functionalization into the ortho, not into the meta position. b N/P-containing group directed meta-C–H functionalization via Ru-catalyzed σ-bond activation. c This work: ligand-enabled meta-C–H alkylation of ArCO2H with alkyl halides.
